A Guide to Alternative Cannabinoids

In recent years, the cannabis industry has seen a surge in popularity, not only due to the legalization of cannabis in many parts of the world but also because of the growing interest in alternative cannabinoids. 

While most people are familiar with THC (tetrahydrocannabinol) and CBD (cannabidiol), there is a fascinating world of lesser-known cannabinoids that are gaining attention for their potential therapeutic effects. In this guide, we will explore some of the most intriguing alternative cannabinoids, including Delta-8, Delta-10, HHC, THC-P, and THC-O.

Understanding Alternative Cannabinoids

Before diving into the specific cannabinoids, let’s first understand what alternative cannabinoids are. Cannabis plants contain over 100 different cannabinoids, each with its own unique properties and effects on the body’s endocannabinoid system. 

While THC and CBD are the most well-known cannabinoids, alternative cannabinoids are those that exist in smaller quantities within the plant and have recently gained attention for their potential benefits.

Due to the Farm Bill of 2018, many alternative cannabinoids have gained legal recognition and can be derived from hemp, which contains less than 0.3% Delta-9 THC. This has opened up opportunities for research, development, and commercialization of these compounds.

It’s important to note that while alternative cannabinoids are derived from cannabis plants, their effects may differ from the well-known THC and CBD. Each cannabinoid interacts with the body’s endocannabinoid system in unique ways, which contributes to their distinct effects and potential benefits.


Delta-8-tetrahydrocannabinol, or Delta-8 THC, has emerged as a popular alternative to traditional THC. It is chemically similar to Delta-9 THC, the psychoactive compound responsible for the “high” associated with cannabis, but with some differences in its molecular structure. 

Delta-8 is known for producing a milder psychoactive effect, often described as more clear-headed and less anxiety-inducing than Delta-9 THC. Additionally, Delta-8 is legal in many places where Delta-9 THC is not, making it an appealing choice for those seeking a legal high and balanced experience.


Delta-10-tetrahydrocannabinol, or Delta-10 THC, is a relatively new cannabinoid that has gained attention for its unique properties. Like Delta-8, Delta-10 has a molecular structure similar to Delta-9 THC. However, it possesses a different arrangement of double bonds, resulting in distinct effects. 

Delta-10 is known for its uplifting and energizing qualities, making it a popular choice for those looking for a more stimulating experience. While Delta-10 is still being researched, initial findings suggest potential therapeutic applications and an enjoyable recreational experience.


Hexahydrocannabinol, or HHC, is a lightly intoxicating cannabinoid that offers an alternative for individuals who prefer not to experience the intense psychoactive effects of THC. HHC is derived from Delta-9 THC through a chemical process that converts it into a new compound. 

While HHC interacts with the endocannabinoid system, its effects are reported to be more subtle and less impairing than Delta-9 THC. This makes HHC an interesting option for those seeking potential therapeutic benefits without the intense psychoactive effects associated with THC.


Tetrahydrocannabiphorol, or THC-P, is a lesser-known cannabinoid that has gained attention for its exceptional potency. THC-P is reported to be significantly more potent than Delta-9 THC, meaning that smaller doses may produce a similar or stronger effect. While the research on THC-P is limited, its potential therapeutic applications and enhanced potency make it an intriguing cannabinoid worth keeping an eye on. This compound is most commonly seen in vapes and edibles, such as those in our most recent Eighty Six Brand review.


THC-O-acetate, or THC-O, is a synthetic cannabinoid that is chemically similar to Delta-9 THC but with an added acetyl group. This modification enhances its potency, resulting in a more intense psychoactive experience even at lower doses. 

THC-O is known for its euphoric and sedating effects, often described as a more psychedelic and prolonged high compared to traditional THC.

Exploring the Potential Benefits

While the research on alternative cannabinoids is still in its early stages, there is growing interest in their potential therapeutic benefits. Here are some of the areas where these cannabinoids are being investigated:

Pain Management

Cannabinoids, including Delta-8, Delta-10, and HHC, have shown promise in providing relief from chronic pain conditions. They may interact in unique ways with the endocannabinoid system, which plays a role in regulating pain perception, inflammation, and other bodily functions.

Anxiety and Stress Relief

Some individuals find that alternative cannabinoids, such as Delta-8 and HHC, offer a more relaxed and calming experience compared to traditional THC, potentially making them useful for managing anxiety and stress.

Appetite Stimulation 

Delta-8 and Delta-10 have been reported to stimulate appetite, which could be beneficial for individuals dealing with appetite loss due to medical conditions or treatments.

Sleep Support

Certain alternative cannabinoids may have sedative properties that could aid in promoting better sleep and managing sleep-related issues. THC-P seems promising for this purpose, given its extremely high potency.

Mood Enhancement

Delta-8, Delta-10, and THC-O have been associated with mood-enhancing effects, potentially offering an alternative for individuals seeking a more uplifting experience.

It’s important to remember that the effects and benefits of these cannabinoids may vary from person to person, and more research is needed to fully understand their potential therapeutic applications.

Navigating Legalities and Safety Considerations

As with any cannabinoid, it’s crucial to be aware of the legal and safety aspects associated with alternative cannabinoids. The legal status of these cannabinoids can vary depending on your jurisdiction, so it’s essential to research and understand the regulations in your specific area.

Moreover, due to limited research and regulation, the production and quality control of alternative cannabinoids may vary. It’s advisable to purchase products from reputable sources that provide third-party lab testing results to ensure purity, potency, and safety.

Additionally, it’s crucial to consult with a healthcare professional before using alternative cannabinoids, especially if you have any underlying medical conditions or are taking medications. They can provide personalized guidance based on your specific circumstances and help you make informed decisions.

In Summary

The world of alternative cannabinoids is a fascinating realm that holds promise for both recreational and therapeutic purposes. From Delta-8 and Delta-10 to HHC, THC-P, and THC-O, these lesser-known cannabinoids offer a variety of effects and potential benefits. 

However, it’s important to approach their use with caution, keeping in mind legalities, safety considerations, and the need for further research to fully understand their effects and applications. As the cannabis industry continues to evolve, alternative cannabinoids may become increasingly popular and integrated into various products. 

Whether you’re curious about exploring new experiences or seeking potential therapeutic benefits, it’s always wise to stay informed, consult professionals, and make mindful choices when it comes to your well-being and cannabinoid usage.

Intrigued? Our Hi On Nature Reviews have some delicious alt cannabinoid content!